What if genetically engineered plants & organisms would screen the flow of people & goods in our ports? What if climate change & shifting global geopolitical/economic power alter the routes and nature of shipping? What if new measures for progress beyond GDP shake up value & supply chains? Back in 2017 the Zeeland Seaports (Vlissingen and Terneuzen) and the Ghent Port Company merged into the cross-border North Sea Port, becoming a new European top 10-player. In the context of their latest joint strategy development process, I was asked to challenge & inspire participants’ views of the future with a keynote focussing on key external developments potentially impacting the future of the North Sea Port’s ecosystem.